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Healthcare & Biomedical

Patient-flow in hospitals, medical device models, epidemiology, pharmacokinetics

13 articles

Article

Monolix Population PK-PD Modeling: Nonlinear Mixed-Effects Estimation for Drug Development

Monolix is a leading nonlinear mixed-effects (NLME) modeling platform for population pharmacokinetic-pharmacodynamic (PK-PD) analysis, using the SAEM algorithm for robust parameter estimation across diverse patient populations. This guide covers two-compartment PK modeling, Emax PD linking, automated covariate selection, and regulatory submission workflows.

By Jeff 140 views
Article

GATE Monte Carlo Simulation: Optimizing PET/SPECT Scanner Design and Dosimetry in Nuclear Medicine

GATE (Geant4 Application for Tomographic Emission) is the open-source Monte Carlo platform purpose-built for nuclear medicine imaging simulation, enabling medical physicists to model complete PET and SPECT systems from radiotracer decay through detector response. This article covers GATE's core architecture, digitizer chain configuration, NECR characterization, targeted radionuclide therapy dosimetry workflows, and the GPU acceleration capabilities introduced in GATE 10.

By Jeff 155 views
Article

Varian Eclipse TPS: Monte Carlo-Class Dose Calculation with Acuros XB for Lung SBRT

Varian Eclipse's Acuros XB algorithm solves the Linear Boltzmann Transport Equation to deliver Monte Carlo–class dose calculation accuracy in clinical treatment planning workflows. This article examines how Acuros XB outperforms conventional pencil-beam convolution in lung heterogeneity, with a focus on SBRT plan evaluation, DVH analysis, and GPU-accelerated adaptive radiotherapy. Commissioning requirements per AAPM TG-114 and TG-244 are also addressed.

By Jeff 205 views
Article

ANSYS Fluent for Hemodynamic Simulation: Modeling Blood Flow in Cardiovascular Devices

ANSYS Fluent enables biomedical engineers to simulate pulsatile, non-Newtonian blood flow in cardiovascular devices such as heart valves, ventricular assist devices, and coronary stents. This article covers solver configuration, physiologically realistic boundary conditions, key hemodynamic output metrics, and the V&V protocols required for FDA regulatory submissions. Practical guidance addresses meshing strategy, UDF-driven waveform inputs, Windkessel outlet models, and hemolysis index computation.

By Jeff 270 views
Article

GastroPlus ACAT Model: Predicting Oral Drug Bioavailability with Mechanistic Absorption Simulation

GastroPlus uses its Advanced Compartmental Absorption and Transit (ACAT) model to mechanistically simulate oral drug absorption across nine physiologically distinct GI compartments. This article explores how pharmaceutical scientists configure the model, predict food effects, and generate regulatory-ready bioavailability data for IND and NDA submissions. Practical guidance covers physicochemical inputs, formulation definition, sensitivity analysis, and population variability modeling.

By Jeff 361 views