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Healthcare & Biomedical

Patient-flow in hospitals, medical device models, epidemiology, pharmacokinetics

11 articles

Article

Varian Eclipse TPS: Monte Carlo-Class Dose Calculation with Acuros XB for Lung SBRT

Varian Eclipse's Acuros XB algorithm solves the Linear Boltzmann Transport Equation to deliver Monte Carlo–class dose calculation accuracy in clinical treatment planning workflows. This article examines how Acuros XB outperforms conventional pencil-beam convolution in lung heterogeneity, with a focus on SBRT plan evaluation, DVH analysis, and GPU-accelerated adaptive radiotherapy. Commissioning requirements per AAPM TG-114 and TG-244 are also addressed.

By Jeff 47 views
Article

ANSYS Fluent for Hemodynamic Simulation: Modeling Blood Flow in Cardiovascular Devices

ANSYS Fluent enables biomedical engineers to simulate pulsatile, non-Newtonian blood flow in cardiovascular devices such as heart valves, ventricular assist devices, and coronary stents. This article covers solver configuration, physiologically realistic boundary conditions, key hemodynamic output metrics, and the V&V protocols required for FDA regulatory submissions. Practical guidance addresses meshing strategy, UDF-driven waveform inputs, Windkessel outlet models, and hemolysis index computation.

By Jeff 126 views
Article

GastroPlus ACAT Model: Predicting Oral Drug Bioavailability with Mechanistic Absorption Simulation

GastroPlus uses its Advanced Compartmental Absorption and Transit (ACAT) model to mechanistically simulate oral drug absorption across nine physiologically distinct GI compartments. This article explores how pharmaceutical scientists configure the model, predict food effects, and generate regulatory-ready bioavailability data for IND and NDA submissions. Practical guidance covers physicochemical inputs, formulation definition, sensitivity analysis, and population variability modeling.

By Jeff 193 views